主要从事领域为荧光探针与生物成像，通过有机合成、结构调控构建新型荧光探针，用于生物重大事件、重大疾病中的分子过程研究，包括
（1）活性小分子的实时、原位、定量探测，如活性氧、活性硫、金属物种、微量元素等

（2）生物大分子检测，如核酸、蛋白、酶等，尤其是表观遗传相关修饰碱基的定量、测序

（3）亚细胞结构荧光标记与特殊微环境显像，如线粒体、溶酶体、内质网等细胞器，或pH、黏度、极性等特殊微环境

科研项目

1. 国家自然科学基金青年项目，22307104，基于串联反应的N6-甲基腺嘌呤选择性检测方法研究，2024-01至2026-12，30万元，在研，主持

2. 四川省自然科学基金面上项目，2023NSFSC0637, 高信噪比近红外pH荧光探针的设计及在肿瘤成像中的应用，2023-01至2021-12，20万元，在研，主持

3. 西华大学人才引进项目，RZ2100000773，基于FRET策略构建多功能荧光探针检测核酸表观遗传修饰，2021-09至2022-12，15万元，结题，主持

学术论文

22. Wang, N.; Zhou, Q.*; Luo, X. L.; Zhang, Y. M.; Li, K.; Yu, X. Q.*, A facile strategy to construct biocompatible fluorescent nanoparticles for intracellular bioimaging. Polymer, 2024, 290, 126486.

21. Jiang, T.; Zhou, Q.; Yu, K. K.; Chen, S. Y.; Li, K.*, Identification and quantification of N6-methyladenosine by chemical derivatization coupled with 19F NMR spectroscopy. Organic & Biomolecular Chemistry, 2024, 22, 2566-2573.

20. Zhou, Q.#; Wang, S. Q.#; Ran, X. Y.#; Shen, L. Z.; Luo, X. L.; Wang, G.; Yang, H.; Wang, Z. Y.*; Yu , X. Q.*, The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite. Chinese Chemical Letters 2023, 34(6), 107922.

19. Li, N.#; Zhou, Q.#; Li, K.*; Jiang, T.; Yu, X. Q.*, Qualitative and quantitative detection of aldehydes in DNA with 2-amino benzamidoxime derivative. Chinese Chemical Letters 2023, 34 (1), 107471.

18. Yan, Li; Liao, C. S.; Zhu, Y. X.; Mi, H. D.; Jiang, S. S.; Shan, F. S.; Liu, Y. H.; Zhang, Y. H.; Zhou, Q.; Wang, Z. Y.*; Yu, X. Q., Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy. ACS Applied Nano Materials, 2023, 6(14), 13320-13329.

17. Zhou, Q.; Chen, Q. Y.; Wu, T. H.; Luo, X. L.; Chen, S. Y.*; Li, K.; Yu, X. Q.*, Fast and selective fluorescent labelling of 5-formyluracil based on Knoevenagel reaction and its application in cell imaging. Journal of Luminescence 2022, 251, 119236.

16. Ran, X. Y.#; Zhou, Q.#; Zhang, J.; Wang, S. Q.; Wang, G.; Yang, H.; Liu, X. C.; Wang, Z. Y.*; Yu, X. Q.*, A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging. Organic Chemistry Frontiers 2021, 8 (14), 3631-3638.

15. Shan, F. S.; Xia, H. Y.; Xie, X. Y.; Fu, L. J.; Yang, H.; Zhou, Q.; Zhang, Y. Y.; Wang, Z. Y.*; Yu, X. Q., Novel N-doped carbon dots prepared via citric acid and benzoylurea by green synthesis for high selectivity Fe(III) sensing and imaging in living cells. Microchemical Journal 2021, 167, 106273.

14. Zhou, Q.; Li, K.*; Yu, K. K.; Li, N.; Shi, L.; Chen, H.; Chen, S. Y.; Yu, X. Q.*, Aqueous Wittig reaction-mediated fast fluorogenic identification and single-base resolution analysis of 5-formylcytosine in DNA. Chemical Communications 2020, 56 (81), 12158-12161.

13. Zhou, Q.; Li, N.; Li, K.; Yu, X. Q.*, Detection of 5-Formylpyrimidines in DNA Based on Chemoselective Labeling. Progress in Chemistry 2020, 32 (11), 1634-1650.

12. Shi, L.; Li, K.*; Liu, Y. H.; Liu, X.; Zhou, Q.; Xu, Q.; Chen, S. Y.; Yu, X. Q.*, Bio-inspired assembly in a phospholipid bilayer: effective regulation of electrostatic and hydrophobic interactions for plasma membrane specific probes. Chemical Communications 2020, 56 (25), 3661-3664.

11. Shi, L.; Liu, Y. H.; Li, K.*; Sharma, A.; Yu, K. K.; Ji, M. S.; Li, L. L.; Zhou, Q.; Zhang, H.; Kim, J. S.*; Yu, X. Q.*, An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems. Angewandte Chemie International Edition 2020, 59 (25), 9962-9966.

10. Zhou, Q.; Li, K.*; Li, L. L.; Yu, K. K.; Zhang, H.; Shi, L.; Chen, H.; Yu, X. Q.*, Combining Wittig Olefination with Photoassisted Domino Reaction To Distinguish 5-Formylcytosine from 5-Formyluracil. Analytical Chemistry 2019, 91 (15), 9366-9370.

9. Li, K.; Li, L. L.; Zhou, Q.; Yu, K. K.; Kim, J. S.*; Yu, X. Q.*, Reaction-based fluorescent probes for SO2 derivatives and their biological applications. Coordination Chemistry Reviews 2019, 388, 310-333.

8. Li, L. L.; He, P. Y.; Shi, L.; Pan, S. L.; Li, M. Y.; Zhou, Q.; Zhang, H.; Wang, N.; Li, K.*; Yu, X. Q.*, A near-infrared water-soluble fluorescent probe for the detection of biothiols in living cells and Escherichia coli. Analytical Methods 2019, 11 (6), 821-826.

7. Zhou, Q.; Li, K.*; Liu, Y. H.; Li, L. L.; Yu, K. K.; Zhang, H.; Yu, X. Q.*, Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging. Chemical Communications 2018, 54 (97), 13722-13725.

6. Li, L. L.; Li, K.*; Li, M. Y.; Shi, L.; Liu, Y. H.; Zhang, H.; Pan, S. L.; Wang, N.; Zhou, Q.; Yu, X. Q.*, BODIPY-Based Two-Photon Fluorescent Probe for Real-Time Monitoring of Lysosomal Viscosity with Fluorescence Lifetime Imaging Microscopy. Analytical Chemistry 2018, 90 (9), 5873-5878.

5. Shi, L.; Li, K.*; Li, L. L.; Chen, S. Y.; Li, M. Y.; Zhou, Q.; Wang, N.; Yu, X. Q.*, Novel easily available purine-based AIEgens with colour tunability and applications in lipid droplet imaging. Chemical Science 2018, 9 (48), 8969-8974.

4. Yu, K. K.; Li, K.*; Qin, H. H.; Zhou, Q.; Qian, C. H.; Liu, Y. H.; Yu, X. Q.*, Construction of pH-Sensitive Submarine Based on Gold Nanoparticles with Double Insurance for Intracellular pH Mapping, Quantifying of Whole Cells and in Vivo Applications. ACS Applied Materials & Interfaces 2016, 8 (35), 22839-22848.

3. Fang, X. J.; Jeyakkumar, P.; Avula, S. R.; Zhou, Q.; Zhou, C. H.*, Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents. Bioorganic & Medicinal Chemistry Letters 2016, 26 (11), 2584-2588.

2. Ling, Y.; Gao, Z. F.; Zhou, Q.; Li, N. B.*; Luo, H. Q.*, Multidimensional Optical Sensing Platform for Detection of Heparin and Reversible Molecular Logic Gate Operation Based on the Phloxine B/Polyethyleneimine System. Analytical Chemistry 2015, 87 (3), 1575-1581.

1. Ling, Y.; Qu, F.; Zhou, Q.; Li, T.; Gao, Z. F.; Lei, J. L.; Li, N. B.*; Luo, H. Q.*, Diverse States and Properties of Polymer Nanoparticles and Gel Formed by Polyethyleneimine and Aldehydes and Analytical Applications. Analytical Chemistry 2015, 87 (17), 8679-8686.

专利

1. 李坤; 周倩; 余孝其 ; 衍生醛基嘧啶的方法、检测5-醛基胞嘧啶的方法以及醛基嘧啶衍生物的应用, 2019-1-28, 中国, ZL201910079972.7

2. 余孝其; 李坤; 周倩 ; 基于香豆素骨架的Wittig试剂及其制备方法和用途, 2018-1-15, 中国, ZL201810035548.8

3. 余孝其; 王周玉; 周倩; 冉小云; 王桂; 邓小春; 赵静; 邓铭明 ; 一种新型次氯酸根荧光探针、其制备方法及其用于次氯酸根检测的方法, 2020-11-12, 中国, CN202011262822.9

4. 王周玉; 余孝其; 周倩; 冉小云; 王善强; 刘小春; 张锦; 唐会 ; 一种双环吡啶酮类衍生物、其合成方法及其用途, 2020-11-17, 中国, CN202011287793.1

讲授课程：《仪器分析》、《仪器分析实验》、《化学生物学》、《综合化学实验》

全国大学生生命科学竞赛四川赛区暨四川省大学生“生命之星”科技竞赛优秀指导老师（全国二等奖）

西华大学“大学生创新创业训练计划”指导老师