主要从事基于靶点的活性候选分子发现、结构优化与活性机制研究，并结合有机合成方法学研究、药物设计、化学生物学等技术在药物研发中的应用，进而开展创新小分子药物的研发。

1、针对重要药物靶标的活性候选分子发现、结构优化与活性机制研究。

2、天然活性物质的结构优化研究。

3、重要医药中间体的有机合成方法及工艺研究

以第一或通讯作者发表的论文：

1. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor that Shows Activity in a Mouse Model of Parkinson's Disease. Journal of Medicinal Chemistry, 2021

2. Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection, Bioorganic Medicinal Chemistry, 2021
   

3. One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds. Chinese Chem. Lett., 2021

4.  Recent advances in catalytic atroposelective construction of pentatomic heterobiaryl scaffolds. ChemCatChem, 2021

5. Recent advances for alkaloids as botanical pesticides for use in organic agriculture. International Journal of Pest Management,2021

6. Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020

7. Discovery of [1,2,4]Triazole Derivatives as New Metallo-β-Lactamase Inhibitors， Molecules，2020

8. 4,6-Substituted-1H-indazoles as potent IDO1/TDO dual inhibitors. Bioorganic Medicinal Chemistry, 2019

9. Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. MedChemComm, 2019

10. Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. MedChemComm, 2019

11. Thiourea catalysed reduction of α-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water. RSC Advances, 2017

12. Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for Type 2 diabetes. Future medicinal chemistry, 2016

13. IDO as a drug target for cancer immunotherapy: recent developments in IDO inhibitors discovery. RSC Advances, 2016

14. Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2, 3-dioxygenase 1 (IDO1) inhibition properties. Bioorganic Medicinal Chemistry, 2016

15. An efficient way to synthesize n-(β-nitroalkyl) amides through Ritter reaction. Letters in Organic Chemistry, 2015

16. Catalyst-free chemoselective reduction of the carbon–carbon double bond in conjugated alkenes with Hantzsch esters in water. RSC Advances, 2014

17. Synthesis and biological evaluation of Raddeanin A, a triterpene saponin isolated from Anemone raddeana. Chemical Pharmaceutical Bulletin, 2012

18. Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B. Journal of Natural Products, 2010

19. 齐墩果酸γ-内酯衍生物的合成及活性评价. 高等学校化学学报, 2012

20. Synthesis and α-glucosidase inhibitory activity of oleanolic acid derivatives. Journal of Asian Natural Products Research, 2010

21. Synthesis and characterization of new liver targeting 5-fluorouracil-cholic acid conjugates. Archiv der Pharmazie, 2009

22. Synthesis of (S) and (R)-tilisolol hydrochloride. Chinese Chemical Letters, 2009

23. Synthesis of an optically active intermediate for A-ring of 19-nor-1α, 25-dihydroxyvitamin D3. Chinese Chemical Letters, 2007

以第一发明人的授权专利：

2016100810173、2017100539684、201610831550、201710230125、201610040272、201610014976、201510299055、201410557329等

主讲药物化学、天然药物化学、仪器分析与波谱解析、制药工程专业导论等专业核心或必修课程。

获四川省学术与技术带头人后备人选、四川省杰出青年培育计划、西华大学优秀科技工作者、唐立新“优秀学者”奖、西华大学“西华学者培养计划”、西华大学首届“青年学者培养计划”、西华大学青年教师讲课比赛三等奖。

任四川省药学会药物化学专委会委员，中国药学会高级会员，中国化学会会员，ACS Med Chem Lett、Bioorg. Med. Chem.、Bioorg. Med. Chem. Lett.等多个药学领域SCI期刊的审稿人。